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. 2022 Jun 7;4(1):e000240. doi: 10.1136/bmjno-2021-000240

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Change in CLA with natalizumab versus placebo. Natalizumab reduced CLA as measured by both (A, B) absolute increase and (C, D) percentage increase in T1LV in SELs and non-SELs compared with placebo in patients with SPMS. Distribution-free quantile confidence limits are displayed. P values by Van Elteren test; stratified by baseline EDSS Score (≤5.5 or ≥6.0) and baseline T2 lesion volume category based on tertiles (≤6908.79 mm³, >6908.79–18 818.49 mm³ and >18 818.49 mm³). BL, baseline; CLA, chronic white matter lesion activity; EDSS, Expanded Disability Status Scale; SPMS, secondary progressive multiple sclerosis; T1LV, T1-hypointense lesion volume.