Table 2. Hazard Ratios (HRs) and 95% CIs for the Primary and Secondary End Points.

End point	No. with DED end point		HR (95% CI)a	P value
	Placebo (n = 11 766)	ω-3 Fatty acids (n = 11 757)
Primary (incident DED)	240	232	0.97 (0.81-1.16)	.72
Secondary (incident DED plus incident severe DED symptoms)	1074	1044	0.97 (0.89-1.06)	.49
Excluding year 1
Primary (incident DED)	198	200	1.01 (0.83-1.23)	.91
Secondary (incident DED plus incident severe DED symptoms)	854	846	0.99 (0.90-1.09)	.81
Excluding years 1-2
Primary (incident DED)	149	145	0.97 (0.77-1.22)	.82
Secondary (incident DED plus incident severe DED symptoms)	597	611	1.02 (0.91-1.14)	.72

Abbreviation: DED, dry eye disease.

^a Adjusted for age, sex, and vitamin D treatment assignment.