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. 2022 Jun 8;10(6):e004512. doi: 10.1136/jitc-2022-004512

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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The pretreatment peripheral TCR clonotyping is prognostic for overall survival. (A–C) Kaplan-Meier survival curves comparing patients with oligoclonal and polyclonal TCR repertories in (A) all patients; (B) HPV-negative patients and (C) who are ever smokers. (D) Summary of results from the Cox proportional hazards regression model (to test the association with clonotyping and overall survival) by adjusting age, smoking, productive templates. HPV, human papillomavirus; IHC, immunohistochemistry; TCR, T cell receptor.