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. 2022 Jun 8;10(6):e004512. doi: 10.1136/jitc-2022-004512

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Association between TCR repertoire diversity in baseline PBMC and clinical outcomes of patients with HNSCC. (A) The CR/PR patients have the lowest productive Simpson Clonality score, followed by SD and PD. (B) The never smoked patients with HNSCC show significantly lower productive Simpson clonality (p=0.015) in contrast to ever smokers. (C) The further stratification by HPV status shows the similar pattern of diversity discrepancy driven by smoking status. CR, complete response; HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; PBMC, peripheral blood mononuclear cells; PD, progressive disease; PR, partial response; SD, stable disease; TCR, T cell receptor.