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. 2022 Jun 8;10(6):e004512. doi: 10.1136/jitc-2022-004512

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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The GIANA clustering analysis revealed shared clonotypes across responder patients. (A) The clonotype clustering analysis of all HPV-negative responders (CR/PR) based on the distance calculated from the software GIANA. Sequences of special interest are marked with an asterisk (*). (B) The combined GIANA clustering reveals shared clones between peripheral TCR repertoires of CR patients and tumor samples from TCGA-HNSC. (C) The sequence logo plot shows the amino acid pattern of all CDR3 reads in CP/PR patients matched to the sequences retrieved from TCGA-HNSC. CDR3, complementarity-determining region 3; CR, complete response; PR, partial response; TCR, T cell receptor.