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. 2022 May 15;12(5):2032–2049.

Table 5.

Univariate Cox regression analysis of risk factors associated with OS and PFS from the development cohort

Variables OS PFS


HR 95% CI P HR 95% CI P
Gender 0.491 0.571
    Male 1 1
    Female 1.163 0.756~1.79 1.121 0.754~1.667
Age, years 0.333 0.457
    ≤ 60 1 1
    > 60 1.25 0.796~1.962 0.858 0.574~1.284
Tumor location 0.998 0.698
    head 1 1
    body and tail 1.001 0.517~1.94 1.119 0.633~1.978
Maximum diameter of tumor 0.515 0.853
    ≤ 4 cm 1 1
    > 4 cm 0.859 0.543~1.358 1.04 0.684~1.582
Differentiated degree < 0.001 < 0.001
    High 1 1
    Medium 1.938 0.874~4.299 2.037 0.958~4.329
    Low 15.773 6.321~39.355 22.944 9.238~56.988
AJCC staging < 0.001 < 0.001
    I 1 1
    II 3.796 1.848~7.799 3.677 1.888~7.163
    III 14.125 5.893~33.856 14.420 6.503~31.976
T staging 0.663 0.839
    T1 1 1
    T2 0.84 0.484~1.46 0.859 0.507~1.454
    T3 0.762 0.423~1.373 0.933 0.535~1.629
N staging < 0.001 < 0.001
    N0 1 1
    N1 3.61 2.038~6.394 3.215 1.905~5.426
    N2 7.641 3.874~15.072 7.443 4.030~13.744
Vascular invasion 0.030 0.044
    No 1 1
    Yes 1.618 1.049~2.497 1.506 1.011~2.245
Nerve invasion 0.103 0.021
    No 1 1
    Yes 1.432 0.93~2.204 1.598 1.073~2.381
BMI (Kg/m2) 0.889 0.720
    < 24 1 1
    ≥ 24 1.031 0.671~1.585 1.076 0.722~1.603
CEA (ng/ml) 0.001 0.010
    ≤ 5 1 1
    > 5 2.468 1.458~4.175 1.851 1.160~2.953
CA19-9 (U/ml) < 0.001 < 0.001
    ≤ 37 1 1
    > 37 2.971 1.885~4.683 3.390 2.201~5.221
Smoking history 0.406 0.860
    No 1 1
    Yes 0.776 0.426~1.413 1.047 0.630~1.740
Drinking history 0.824 0.933
    No 1 1
    Yes 0.944 0.566~1.573 1.020 0.644~1.616
Hypertension 0.208 0.722
    No 1 1
    Yes 0.734 0.454~1.188 0.925 0.603~1.419
Diabetes 0.859 0.403
    No 1 1
    Yes 1.05 0.616~1.788 1.234 0.754~2.017
Clinical symptoms 0.283 0.142
    No 1 1
    Yes 1.737 0.633~4.766 2.128 0.776~5.830
Therapeutic regimen < 0.001 0.022
    Surgery alone 1 1
    Surgery + chemotherapy 0.345 0.217~0.547 0.554 0.362~0.847
    Surgery + radiotherapy 0.481 0.147~1.578 0.650 0.199~2.125
    Surgery + chemoradiotherapy 0 0~3.345 0.945 0.228~3.922
    Other 0.188 0.066~0.534 0.288 0.113~0.734
Rad-score 10.386 5.785~18.648 < 0.001 11.213 6.007~20.932 < 0.001