Table 1.

Methionine restriction or deprivation in combination with various chemotherapies in preclinical models

Methionine restriction to metabolically prime cancer cells
Chemotherapy	Drug Target	Reference(s)
Lexatumumab	Monoclonal agonist antibody for the death receptor TRAIL receptor 2	Strekalova et al. 2015 [150]
Cycloleucine	Methionine adenosyltransferase (MAT) inhibitor	Strekalova et al. 2019 [10]
Auranofin	Thioredoxin reductase (TXNRD) inhibitor	Malin et al. 2021 [65]
Methionine restriction and standard of care chemotherapy
Chemotherapy	Drug Target	Reference(s)
5-Fluorouracil	Thymidylate synthase (TS) inhibitor	Gao et al. 2019 [28]
		Yoshioka et al. 1998 [52]
Cisplatin	Binds DNA and interferes with repair	Poirson-Bichat et al. 2000 [63]
		Tan et al. 1999 [210]
Doxorubicin	Binds and inhibits DNA Topoisomerase II	Poirson-Bichat et al. 2000 [63]
		Stern et al. 1986 [16]
		Nagahama et al. 1998 [170]
Vincristine	Interacts with tubulin to prevent mitotic spindle formation	Stern et al. 1986 [16]
		Nagahama et al. 1998 [170]
Decitabine	DNA demethylating agent	Higuchi [168]
Azacitidine	DNA demethylating agent	Higuchi [169]
Gemcitabine	Pyrimidine antagonist	Kawaguchi [171]