Table 2.
Recent clinical trials utilizing methionine restriction
| Identifier | Status | Recruiting Location | Study Title | Condition(s) | Study Goals |
|---|---|---|---|---|---|
| NCT03186937 | Terminated | University of Wisconsin Madison Carbone Cancer Center | A window of opportunity study of methionine deprivation in triple negative breast cancer | Triple negative breast cancer (TNBC) | • Effect of methionine restriction on TRAIL R2 cell surface expression |
| • Effect on cancer stem cells and metabolic health | |||||
| NCT03574194 | Suspended | West Virginia University Cancer Institute | Methionine-restricted diet to potentiate the effects of radiation therapy | Lung cancer | • Safety and adherence of methionine-restricted diet to radio-sensitize tumors |
| Prostate cancer | |||||
| Breast cancer | |||||
| NCT03733119 | Terminated | University of Wisconsin Madison Carbone Cancer Center | ONC201 with and without methionine-restricted diet in patients with metastatic triple negative breast cancer | Metastatic triple negative breast cancer (TNBC) | • Phase II trial combination methionine restriction and ONC201 (Akt/ERK inhibitor) for response rate |
| NCT00508456 | Terminated | U.T.M.D. Anderson Cancer Center Houston Texas | Dietary Methionine Restriction Plus Temozolomide for Recurrent GBM | Glioblastoma Multiforme | • Safety and tolerability of methionine restriction in combination with temozolomide |
| • Correlate response and survival with serum methionine and peripheral blood lymphocyte methylation | |||||
| NCT00640757 | Completed | Pennington Biomedical Research Center | Methionine-Restriction Diet (MRD) in Obese Adults with Metabolic Syndrome | Metabolic syndrome | • Impact of methionine restricted diet on weight loss and glucose metabolism/tolerance |
| NCT02192437 | Completed | Penn State University State College Milton S. Hershey Medical Center | Dietary Methionine and Cysteine Restriction in Healthy Adults | Healthy Individuals | • Evaluate short- and long-term metabolic changes associated with health-span in response to dietary methionine or methionine-cysteine restriction |
| NCT03629392 | Completed | University of Oslo, Norway | Methionine and Cysteine Restriction in Humans | Overweight Individuals | • Effect of methionine and cysteine restriction on energy and macronutrient metabolism in overweight humans |
| NCT04701346 | Recruiting | University of Oslo, Norway | Sulfur Amino Acids, Energy Metabolism and Obesity (STAY) | Overweight and Obese Individuals | • Effect of dietary SAA restriction on body weight/composition and energy expenditure in humans |
| • Comparison of high SAA and low SAA diet |