Table 1.
Characteristics of patients with breast cancer (n = 135), comparison between low and high cNOTCH1 expression was done
| Characteristic | cNOTCH1 expression | P value | |
|---|---|---|---|
|
| |||
| Low (n = 79) | High (n = 56) | ||
| Age at surgery (years)a | 52 (31-83) | 53 (24-82) | 0.711 |
| Female gender | 79 (100%) | 56 (100%) | > 0.99 |
| Diagnosis | 0.570 | ||
| Invasive ductal carcinoma | 78 (99%) | 54 (96%) | |
| Invasive ductal carcinoma with predominant ductal carcinoma in situ | 1 (1%) | 2 (4%) | |
| Operation methods | 0.973 | ||
| Partial mastectomy and sentinel lymph node biopsy | 5 (6%) | 4 (7%) | |
| Partial mastectomy and axillary lymph node dissection | 6 (8%) | 4 (7%) | |
| Total mastectomy and sentinel lymph node biopsy | 12 (15%) | 10 (18%) | |
| Modified radical mastectomy | 56 (71%) | 38 (68%) | |
| Tumor size (cm)a | 2.5 (0.2-8.0) | 2.4 (0.8-6.5) | 0.087 |
| Tumor stage | 0.139 | ||
| Tis | 1 (100%) | 0 | |
| T1 | 15 (42%) | 21 (58%) | |
| T2 | 59 (64%) | 33 (36%) | |
| T3 | 3 (75%) | 1 (25%) | |
| T4 | 1 (50%) | 1 (50%) | |
| Nodal stage | 0.301 | ||
| N0 | 36 (57%) | 27 (43%) | |
| N1 | 24 (52%) | 22 (48%) | |
| N2 | 8 (67%) | 4 (33%) | |
| N3 | 11 (79%) | 3 (21%) | |
| AJCC TNM stage | 0.063 | ||
| Stage I | 9 (39%) | 14 (61%) | |
| Stage II | 50 (59%) | 34 (41%) | |
| Stage III | 20 (71%) | 8 (29%) | |
| Adjuvant chemotherapy | 65 (82%) | 49 (88%) | 0.476 |
| Subtypes | 0.693 | ||
| ER/PR-positive, HER2-negative | 45 (57%) | 36 (64%) | |
| HER2-positive | 22 (28%) | 13 (23%) | |
| Triple negative breast cancer | 12 (15%) | 7 (13%) | |
Abbreviations: AJCC TNM stage, American Joint Committee on Cancer tumor-node-metastases (TNM) staging system; ER, Estrogen receptor; HER, Human epidermal growth receptor type II; cNOTCH1, Cytosolic NOTCH1 protein; PR, Progesterone receptor.
a
Values are expressed as median (range).