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Summary of cellular BFL1 response to Chk1 inhibition (Chk1i)
| Cell Line Example | BFL1 Protein Response | Apoptotic Cells (%) | ||
|---|---|---|---|---|
|
|
|
|||
| Basal | +Chk1i | +Chk1i+MEKi | +Chk1i | |
| U2OS | Low | Increased | To basal | 67 |
| PANC1 | High | Increased | Decreased cf basal | ND |
| A2058 | High | No change | ND | 71 |
| SJSA-1 | Low | No change | ND | 25 |
ND, not determined; MEKi, MEK inhibitor.
