Table 1.

A. Alterations in MDM2, MDM4, USP7, and PPM1D, and tendencies toward mutual exclusivity or co-occurrence in primary melanoma. B. Alterations in MDM2, MDM4, USP7, and PPM1D, and tendencies toward mutual exclusivity or co-occurrence in metastatic melanoma

A.
A	B	Neither	A Not B	B Not A	Both	Log2 Odds Ratio	p-Value	q-Value	Tendency
USP7	PPM10	331	12	2	1	>3	0.109	0.653	Co-occurrence
MDM4	MDM2	999	18	24	1	1.209	0.372	0.943	Co-occurrence
MDM2	PPM1D	956	24	24	0	<-3	0.556	0.943	Mutual exclusivity
MDM4	PPM1D	961	19	24	0	<-3	0.629	0.943	Mutual exclusivity
MDM4	USP7	331	2	13	0	<-3	0.926	-0.962	Mutual exclusivity
MDM2	USP7	332	1	13	0	<-3	0.962	0.962	Mutual exclusivity
B.
A	B	Neither	A Not B	B Not A	Both	Log2 Odds Ratio	p-Value	q-Value	Tendency
USP7	PPM1D	267	11	8	5	>3	<0.001	0.002	Co-occurrence
MDM4	USP7	260	15	13	3	2.000	0.067	0.201	Co-occurrence
MDM2	PPM1D	259	19	11	2	1.309	0.239	0.478	Co-occurrence
MDM2	USP7	256	19	14	2	0.945	0.324	0.486	Co-occurrence
MDM4	MDM2	312	18	26	1	-0.585	0.570	0.572	Mutual exclusivity
MDM4	PPM1D	261	17	12	1	0.355	0.572	0.572	Co-occurrence