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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: FEBS J. 2021 Dec 4;290(1):28–36. doi: 10.1111/febs.16278

Figure 1: Model of inflammasome activation that leads to IL-1b release in CNV macrophages and retinal microglia.

Figure 1:

In response to specific stimuli, PRRs oligomerize and form together with the adaptor protein ASC scaffolds that activate caspase-1. Caspase-1 activation products are necessary for the proteolytic processing of pro-IL-1β to active IL-1β that once secreted can promote neovascularization. Whereas NLRP3 is an established PRR that can trigger the inflammasome in CNV macrophages/microglia, which non-NLRP3 PRRs can do this as well is currently unknown.