Figure 22.

Radiolabeled bone marrow cells in bone fracture models. Longitudinal PET/CT imaging of ⁸⁹Zr-labeled bone marrow cells administered intravenously in control mice (A), injected 1 day before tibial fracture (B), or injected on the same day as the fracture (C). In both fracture models, bone marrow cells can be seen accumulating at the fracture site (orange arrows) within 1 day of administration. In model B, the accumulation of labeled cells at the fracture site represents remobilization of administered bone marrow from organs they had initially trafficked to. Adapted with permission from Asiedu et al., ref (78). Copyright 2018 Asiedu et al. Published by Springer Nature under CC license [https://creativecommons.org/licenses/by/4.0/].