Skip to main content
. 2022 May 12;122(11):10266–10318. doi: 10.1021/acs.chemrev.1c00767

Table 7. Examples of Clinical Applications of Direct Cell Labeling.

cell type application radionuclide/tracer refs
infection and inflammation
WBCs musculoskeletal infections (e.g., osteomyelitis, spondylodiscitis, prosthetic joints, cardiovascular implants) 111In-oxine, [99mTc]Tc-HMPAO, [18F]FDG numerous, see, e.g., refs (189, 311313)
neutrophils chronic obstructive pulmonary disease 111In-oxine, [99mTc]Tc-HMPAO, 111In-tropolone (314318)
eosinophils asthma [99mTc]Tc-HMPAO (234, 241, 319)
       
cardiovascular
RBCs transfusion recovery 51Cr (320)
cardiac function 99mTc (321)
cerebral blood volume 99mTc (322)
detection of bleeding 99mTc, [18F]FDG (323325)
platelets deep vein thrombosis, pulmonary embolism 111In-oxine, [99mTc]Tc-HMPAO (326329)
atherosclerosis 111In-oxine (330)
       
transplantation
hepatocytes liver diseases 111In-oxine (331, 332)
mesenchymal stem cells cirrhosis 111In-oxine (63)
peripheral blood stem cells, bone marrow stem cells myocardial infarction [18F]FDG, 111In-oxine (239, 240, 333, 334)
PBMCs graft rejection 99mTc + SnCl2 (335)
WBCs graft rejection 111In-oxine, [99mTc]Tc-HMPAO (336)
       
oncology
tumor-infiltrating lymphocytes metastatic melanoma 111In-oxine (304, 337)
purified antigen-specific T cells metastatic melanoma, breast cancer 111In-oxine (309, 310)
gammadelta (γδ) T cells melanoma, ovarian cancer, colon cancer, adenocarcinoma, breast cancer, duodenal cancer, cervical cancer, cholangiocarcinoma 111In-oxine (338)
dendritic cells multiple myeloma, renal cell carcinoma, cervical cancer, lung cancer, myosarcoma 111In-oxine, [18F]FDG, [64Cu]Cu-PTSM, [99mTc]Tc-HMPAO (58, 112, 188, 339)
macrophage activated killer cells ovarian cancer 111In-oxine, [18F]FDG (187)