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. 2022 Jun 10;18(6):39. doi: 10.1007/s11306-022-01898-4

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MALDI-MS-Imaging and H&E staining of spleen samples. Representative images of spleens from three measurements per condition are shown. The measurements include samples of infections with S. aureus strains 113 and LUG2012, S. pneumoniae (colonization), IAV (5 dpi) and S. pneumoniae – IAV co-infection. The compound-related heatmaps illustrate high intensities in yellow and low abundances in purple normalized to total ion count