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. 2022 May 18;22(11):4519–4527. doi: 10.1021/acs.nanolett.2c01334

Figure 1.

Figure 1

CeO2@BSA nanoclusters are synthesized via a BSA-incubation strategy and can effectively scavenge multiple ROS. (A) Scheme illustration of CeO2@BSA nanocluster formation. (B) HRTEM images (50 nm for left and 2 nm for right scale bar). (C) XRD and (D) XPS analyses of CeO2@BSA nanoclusters. (E) TGA analysis of CeO2@BSA nanoclusters and BSA. Concentration dependent multiple ROS scavenging ability evaluation of CeO2@BSA nanoclusters, (F) superoxide anion, hydroxyl radical, and hydrogen peroxide. (G) ESR spectrum of time depended free radicals (superoxide anion and hydroxyl radical) scavenging ability of CeO2@BSA nanoclusters. (H) In vitro ROS scavenging ability of CeO2@BSA nanoclusters in N2a cells (green fluorescence represents ROS) (scale bar: 100 μm) and (I) quantitative analysis (n = 3). Data are shown as mean ± SD. Statistical analysis of (F, I) was performed by one-way ANOVA with a Tukey post hoc test.