Table 3.
Pharmacological treatments of RBD in PD patients.
| - | Recommended Dose | Benefits | Side Effects |
|---|---|---|---|
| Sedating benzodiazepine | |||
| Clonazepam | 0.5-2 mg [105] | reduce RBD events; improve subjective nighttime sleep; reduce phasic EMG activity | worsen OSA; morning sedation; falls; confusion; daytime somnolence |
| Melatonin and Melatonin agonist | |||
| Melatonin | 3-12 mg [86] | reduce RBD-related injuries; improve subjective nighttime sleep | mild headaches; daytime somnolence; fatigue |
| Ramelteon | 8 mg [107] | reduce RBD events; improve subjective nighttime sleep; improve PD motor symptom | daytime somnolence; nausea; lightheadedness; delirium; worsen constipation |
| Dopaminergic agonists | |||
| Rotigotine | 2-16 mg [116] | reduce RBD events; improve PD motor and non-motor symptom; reduce pain | local site reactions; dyskinesias; headache; dizziness; daytime somnolence; fatigue; nausea |
| Others | |||
| Rivastigmine (patch) | 4.6 mg [112] | reduce RBD events; improve subjective nighttime sleep | minor peripheral cholinergic action |
| Memantine | 20 mg [113] | reduce RBD events; improve cognitive function | bradycardia; nausea |