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The influence of zinc on CCK release via inhibition of NMDA receptor. Glutamate due to NMDA receptor can modulate the release of cholecystokinin (CCK). In the pathophysiology of depression, both the hihg CCK as well as high glutamate levels are observed (A). Zinc lowers glutamate levels by the inhibion of glutamatergic NMDA receptor and therefore may attenuate CCK realease (B). (A higher resolution/colour version of this figure is available in the electronic copy of the article).
