Table 3.
Sites of disease, imaging results, trastuzumab therapy history, and follow-up
| Patient | Sites of known disease* | Visualized sites 64Cu-trastuzumab | Sites of disease progression | Time to progression from initial 64Cu-trastuzumab injection (months) | Last follow-up since initial antibody (months) |
Last trastuzumab treatment since initial antibody (months) |
|---|---|---|---|---|---|---|
| 1 | Liver+, bone+ | Liver | Liver, bone lung | 2.8, 7.2, 64.5 | 90.5 | 85 |
| 2 | Lung, bone, brain | Negative | Brain, lung | 12.2, 50.6 | 59.5 | 58 |
| 3 | Liver, bone, mediastinum | Negative | Brain | 51.6 | 85.3 | 85 |
| 4 | Bone+ | Negative | Bone | 17.5 | 42.2 | 33 |
| 5 | Bone+, liver− | Negative | Brain | 8.2 | 62.7 | 38 |
| 6 | Breast+, bone− | Negative | Breast 5.6m, adrenal 28.2m, liver 33.2m, brain 31m, skin 16.6m | 5.6, 28.2, 33.2, 31, 16.6 |
36.1 | 35 |
| 7 | Bone, brain, lung | Negative | Brain | 1.4 | 1.6 | 2 |
| 8 | Breast+ | Breast | N/A | no progression | 74 | 73 |
| 9 | Bone+ | Negative | Bone, liver, brain, abdominal node, and peritoneal carcinomatosis |
4, 17, 23.6, 28.9, 28.9 |
35.1 | 34 |
| 10 | Bone-na | Negative | NA |
no progression | 70 | 70 |
| 11 | Bone-na | Negative | Brain | 5.5 | 32.3 | 6 |
Note: “+” or “−” refers to patients who had FDG in addition to conventional imaging.