UMIN000019017.

Study name	Efficacy of Rho‐kinase inhibitor ophthalmic solution on bleb formation after trabeculectomy, a randomized parallel study
Methods	Basic design: parallel Randomization: randomized Randomization unit: participants Masking: open‐label
Participants	Inclusion criteria: men and women who have trabeculectomy as the therapy of open‐angle glaucoma which is not sufficiently controlled; age ≥ 20 years Key exclusion criteria: people who had intraocular surgeries within 6 months; IOP unable to be measured by Goldmann applanation tonometer; conjunctival surgeries (including glaucoma surgeries); allergy to the ingredients of Rho‐kinase inhibitor ophthalmic solution; used Rho‐kinase inhibitor ophthalmic solution before surgery; pregnant or breast‐feeding; people unsuitable for study according to doctor.
Interventions	Ripasudil 0.4% ophthalmic solution twice per day for 3 months No treatment
Outcomes	Primary outcomes Transition of IOP for 12 months after surgery Bleb scoring at 6 months after surgery
Starting date	1 November 2015 (no longer recruiting); last follow‐up date: 30 September 2022
Contact information	okumic@hiroshima‐u.ac.jp
Notes	Study enrolled 112 participants; results of the study were unpublished.

IOP: intraocular pressure; OHT: ocular hypertension; POAG: primary open‐angle glaucoma.