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. 2021 Sep 6;71(7):1340–1349. doi: 10.1136/gutjnl-2021-324852

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Kaplan-Meier estimates of progression-free survival (PFS) (A) and overall survival (OS) (B) in patients stratified according to different changes in plasma RAS status under first-line treatment Statistical significance was determined by Wald test of the multivariable Cox models. The change in the circulating tumour DNA (ctDNA) fraction of cfDNA, estimated by maximum somatic allele frequency, was included as a variable. mPFS, median progression-free survival; mOS, median overall survival; MUT, mutant; ref, reference; WT, wild-type.