Table 1.
Metabolites of the GMSM panel and their serum abundances and variances (CV% in the C-pool) in untargeted and targeted metabolomic analysis
| Metabolites | Feature | Untargeted metabolomics | Targeted metabolomics | ||||
| Fold change | P value | C pooled-CV (%) | Fold change | P value | C pooled-CV (%) | ||
| 9,12,13-TriHOME (10） | X13_329.233mz_neg | 1.97 | 3.64E-07 | 2.17 | 1.19 | 9.16E-02 | 2.81 |
| (Z)−5,8,11-trihydroxyoctadec-9-enoic acid | X14.3_329.233mz_neg | 0.27 | 4.35E-10 | 2.73 | 0.51 | 2.49E-09 | 4.51 |
| Culinariside | X16.8_420.807mz_pos | 0.68 | 4.35E-10 | 1.66 | 0.87 | 4.24E-01 | 7.8 |
| ((6-([5,7-dihydroxy-2-(4-oxocyclohexa-2,5-dien-1-ylidene)−2H-chromen-3-yl)oxy)−3,4,5-trihydroxyoxan-2-yl)methyl](1-hydroxy-3-(4-hydroxyphenyl)prop-2-en-1-ylidene)oxidanium | X16.9_637.157mz_neg | 0.54 | 4.36E-10 | 2.64 | 0.80 | 4.42E-03 | 5.65 |
| 2-Octenoylcarnitine | X26.2_398.18mz_neg | 9.18 | 4.35E-10 | 0.84 | 10.83 | 1.67E-07 | 1.55 |
| (E)−2-(4,8-dimethylnona-3,7-dien-1-yl)−5-hydroxy-2,7-dimethyl-2H-chromene-8-carbaldehyde | X27.8_353.212mz_neg | 4.79 | 4.35E-10 | 2.06 | 3.34 | 4.37E-10 | 3.17 |
| N, O-Bis- (trimethylsilyl)phenylalanine | X28.5_368.169mz_neg | 6.85 | 4.35E-10 | 1.07 | 8.02 | 4.39E-10 | 4.65 |
| 14-HDoHE | X24_355.228mz_neg | 2.84 | 4.56E-08 | 5.65 | 2.98 | 9.86E-10 | 9.87 |
CV, coefficient of variances; GMSM, gut microbiome-associated serum metabolites.