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. 2022 Jun 10;10:43. doi: 10.1186/s40364-022-00390-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Modified CSC-workflow allows for the interrogation of the AML surfaceome in primary patient samples. A 621 surface proteins identified with our modified CSC technology 7 clinical samples and 1 AML cell line (OCI-AML3), separated into CD proteins (black, 163) and non-CD proteins (red, 458). B Expression levels of CD proteins identified by CSC. Heatmap intensity indicates the log10 average of iBAQ. C Overview of filtering strategy to eliminate targets with abundant expression on normal healthy tissue using publicly available gene expression databases. Furthermore, only proteins that were detected in at least half of the primary patient samples were considered. As a result, 76 proteins remain as potential candidates for manual evaluation. D Protein expression of 5 new putative targets (top, in green) and 6 markers currently being investigated (bottom, in grey) as immunotherapeutic targets in AML samples