Fig. 4.

Candidate antigens display low frequency of non-synonymous mutations, suggesting their functional relevance in hematologic malignancies. A Ratio of Non-synonymous to synonymous mutations in hematologic malignancies found in genome-wide screens in the COSMIC database in genes represented in our surfaceome dataset. Genes are sorted by rank of dN/dS ratio. Selected immunotherapy targets are highlighted. B Ratio of Non-synonymous to synonymous mutations in Non-hematologic malignancies in the COSMIC database. Genes are the same as in A. C Pairwise comparison of relative Non-synonymous mutation rates amongst surfaceome genes between Hematologic and Non-Hematologic malignancies