Table II.
Cognitive and behavioural outcomes at age 9 years of the Groningen ART cohort study groups.
| OS-IVF/ICSI (n = 57) |
MNC-IVF/ICSI (n = 46) |
Sub-NC (n = 66) |
P-value* | |
|---|---|---|---|---|
| WASI | ||||
| Total IQ, mean (95% CI) | 114.7 (83.2–142.6) | 113.8 (90.2–140.8) | 115.1 (87.9–141.2) | 0.746 |
| Verbal IQ, mean (95% CI) | 114.4 (84.2–139.8) | 113.0 (89.0–144.5) | 116.7 (87.9–145.3) | 0.428 |
| Performance IQ, mean (95% CI) | 112.2 (86.8–139.0) | 112.4 (89.0–137.8) | 110.8 (88.7–139.6) | 0.806 |
| Total IQ < 80, n (%) | 1 (2%) | 1 (3%) | 0 (0%) | 0.515 |
| Verbal IQ < 80, n (%) | 1 (2%) | 1 (3%) | 0 (0%) | 0.515 |
| Performance IQ < 80, n (%) | 1 (2%) | 0 (0%) | 1 (2%) | 0.667 |
| NEPSY | ||||
| NEPSY total number of atypical scores, median (range) | 2.0 (0–10) | 2.50 (0–11) | 3.00 (0–9) | 0.347 |
| NEPSY total number of atypical scores on domain attention and executive function, median (range) | 1.50 (0–10) | 2.00 (0–7) | 2.00 (0–6) | 0.651 |
| NEPSY total number of atypical scores on domain memory and learning, median (range) | 0.00 (0–4) | 0.00 (0–3) | 0.00 (0–5) | 0.677 |
| NEPSY total number of atypical scores on domain social cognition, median (range) | 0.00 (0–4) | 0.00 (0–3) | 0.00 (0–5) | 0.677 |
| CBCL | ||||
| CBCL T score on total behaviour problems, mean (SD) | 51.0 (10.58) | 45.9 (10.81) | 49.1 (9.54) | 0.090 |
| CBCL, T score internalising problems, mean (SD) | 52.1 (10.53) | 46.5 (9.39) | 50.7 (10.56) | 0.119 |
| CBCL, T score externalising problems, mean (SD) | 48.4 (9.95) | 44.7 (10.76) | 47.6 (9.62) | 0.167 |
| CBCL atypical T score total behavioural problems, n (%) | 14 (25%) | 4 (9%) | 10 (16%) | 0.116 |
| CBCL atypical T score internalising problems, n (%) | 14 (25%) | 3 (7%) | 13 (21%) | 0.061 |
| CBCL atypical T score externalising problems, n (%) | 9 (16%) | 3 (7%) | 8 (13%) | 0.389 |
| TRF | ||||
| TRF T score total behaviour problems, mean (SD) | 49.6 (7.89) | 48.6 (8.22) | 50.4 (7.79) | 0.507 |
| TRF T score internalising problems, mean (SD) | 51.1 (10.48) | 49.6 (8.48) | 49.4 (9.01) | 0.760 |
| TRF T score externalising problems, mean (SD) | 47.0 (6.32) | 48.9 (7.07) | 50.1 (7.41) | 0.072 |
| TRF atypical T score total behavioural problems, n (%) | 4 (9%) | 4 (10%) | 8 (14%) | 0.722 |
| TRF atypical T score internalising problems, n (%) | 9 (20%) | 6 (14%) | 7 (12%) | 0.477 |
| TRF atypical T score externalising problems, n (%) | 2 (5%) | 3 (7%) | 6 (10%) | 0.562 |
CBCL: Child Behaviour Checklist, TRF: Teacher Report Form, WASI: Wechsler Abbreviated Scale of Intelligence, IQ: intelligence quotient, n: number,*tested with Kruskall–Wallis test