Table III.
Multiple regression analyses of the effect of OS, the in vitro procedure, a combination of both and TTP on IQ, NEPSY, CBCL and TRF.
| Outcome variable | Adjusted regression coefficient (95% CI) | |||
|---|---|---|---|---|
| OS-IVF/ICSI versus MNC IVF/ICSI | MNC-IVF/ICSI versus Sub-NC | OS-IVF/ICSI versus Sub-NC | TTP (in the pooled subfertile group) | |
| Total IQa | 2.57 (−3.54–8.67) | −1.37 (−7.17–4.42) | 1.19 (−4.42–6.81) | −0.88 (−1.71–0.50) |
| Verbal IQb | 3.93 (−2.71–10.58) | −3.71 (−10.02–2.60) | 0.22 (−5.90–6.34) | −0.43 (−1.54–0.88) |
| Performance IQ | 0.78 (−5.69–7.25) | 1.21 (−5.00–7.41) | 1.39 (−4.51–7.29) | −1.42 (−2.01–0.33) |
| NEPSYc | −0.78 (−1.82–0.26) | −0.17 (−1.14–0.80) | −0.95 (−1.91–0.01) | −0.04 (−0.23–0.15) |
| CBCL T total | 4.84 (0.79–8.89) | −2.79 (−6.78–1.19) | 2.05 (−1.64–5.73) | 0.09 (−0.30–1.15) |
| CBCL T internalizingd | 6.36 (2.19–10.53)* | −4.76 (−8.74–0.77)* | 1.60 (−2.11–5.32) | 0.45 (−0.28–1.18) |
| CBCL T externalizinge | 3.89 (−0.02–7.81) | −2.81 (−6.66–1.04) | 1.08 (−2.46–4.62) | 0.21 (−0.48–0.89) |
| TRF T totalf | 1.41 (−1.94–4.76) | −1.59 (−4.69–1.51) | −0.18 (−3.30–2.95) | −0.04 (−0.61–0.53) |
| TRF T internalizingg | 2.22 (−1.74–6.17) | 0.51 (−3.16–4.18) | 2.73 (−0.97–6.42) | −0.05 (−0.63–0.72) |
| TRF T externalizingh | −1.58 (−4.52–1.36) | −0.50 (−3.26–2.27) | −2.08 (−4.85–0.70) | 0.08 (−0.42–0.58) |
* P < 0.05.
a
Corrected for educational level of mother.
b
Corrected for educational level of mother and gender.
c
Total number of atypical NEPSY scores. Corrected for gender, vanishing twin, Caesarian section and Apgar score 5 min.
d
ART group: no significant covariates, TTP: corrected for age of father.
e
ART groups: corrected for prematurity, foetal distress and age of mother. TTP: corrected for foetal distress and age of mother.
f
Corrected for gender and vanishing twin.
g
Corrected for vanishing twin.
h
Corrected for vanishing twin and birthweight.