Table 2.

Results of regressing four measures of EAA on the CVH score

	1st generation of epigenetic clocks						2nd generation of epigenetic clocks
	IEAAa			HannumEAAa			PhenoEAAa			GrimEAAa
	Beta	95% CI	p	Beta	95% CI	p	Beta	95% CI	p	Beta	95% CI	p
Seven-component CVH scoresb
CVH score (2-level, 7-point)	− 0.101	[− 0.2475, 0.0458]	0.177	− 0.122	[− 0.2709, 0.0269]	0.108	− 0.350	[− 0.5459, − 0.1550]	4.5E−4	− 0.499	[− 0.6222, − 0.3758]	4.2E−15
CVH score (3-level, 14-point)	− 0.074	[− 0.1670, 0.0194]	0.120	− 0.083	[− 0.1773, 0.0119]	0.087	− 0.268	[− 0.3919, − 0.1439]	2.4E−5	− 0.364	[− 0.4419, − 0.2865]	1.5E−19
Six-component CVH scoresc
CVH score (2-level, 6-point)	− 0.086	[− 0.2093, 0.0366]	0.169	− 0.088	[− 0.2092, 0.0324]	0.151	− 0.388	[− 0.5528, − 0.2238]	3.9E−6	− 0.526	[− 0.6289, − 0.4222]	6.1E−23
CVH score (3-level, 12-point)	− 0.068	[− 0.1440, 0.0085]	0.082	− 0.065	[− 0.1396, 0.0102]	0.091	− 0.278	[− 0.3798, − 0.1761]	9.6E−8	− 0.377	[− 0.4407, − 0.3136]	2.1E−30

^aIEAA (i.e., intrinsic EAA), HannumEAA, PhenoEAA, and GrimEAA were calculated according to the four epigenetic clocks: Horvath’s clock [11], Hannum et al.’s clock [10], Levine et al.’s PhenoAge [12], and Lu et al.’s GrimAge [13], respectively

^bThe seven-component CVH score was calculated according to the definition of CVH from the American Heart Association (AHA)

^cBecause 42% of the 2474 TWB participants were surveyed by the simplified questionnaire without diet information, the six-component CVH score was calculated without the “ideal diet score.” Other components followed the same definition of the CVH score from the AHA