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. 2022 Jun 9;29:38. doi: 10.1186/s12929-022-00820-3

Fig. 2.

Fig. 2

SRF-cofactor interaction. A Some cofactors can interact with the DNA backbone located adjacent to the CArG box binding site of SRF and associate with SRF directly. B Some cofactors interact directly with SRF because they cannot bind with DNA directly. SRF serum response factor; TCF ternary complex factor; NFAT nuclear factor of activated T cells; MRTF myocardin-related transcription factor; Nkx2.5 NK2 homeobox 5; HOP homeobox protein; and p49/STRAP SRF-dependent transcription regulation-associated protein