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. 2022 Jun 9;29:38. doi: 10.1186/s12929-022-00820-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of SRF and cofactors on mitochondrial gene expression—SRF transcriptional activation exerts an effect on mitochondrial gene expression. One of the major cellular energy-producing pathways is the electron transport chain, and SRF facilitates the activation of complex I via NDUFAB1 action, which is inhibited by p49/STRAP. SRF in association with GATA4 activates CPT1β, which is involved in fatty acid oxidation. p49/STRAP SRF dependant transcription regulation associated protein; SRF Serum response factor; GATA4 GATA binding protein 4; CPT1β carnitine palmitoyltransferase 1β; NDUFAB1 NADH dehydrogenase ubiquinone oxidoreductase subunit AB1