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. 2022 Jun 9;29:38. doi: 10.1186/s12929-022-00820-3

Table 4.

Summary of disease conditions caused due to SRF modulations

Disease Causes References
Heart failure Increased levels of truncated SRF isoform [10, 142]
Cleavage of SRF by Caspase 3 [143]
Dilated cardiomyopathy Cleavage of SRF by enteroviral protease 2A [144]
Decreased SRF Ser103 phosphorylation [149]
Hypertension and arterial stiffness Vascular smooth muscle cell stiffening due to induction of SRF signaling [145–147]
Conotruncal heart defect Loss of transcriptional activity due to SRF gene mutations, 821A > G or 880G > T [148]