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. Author manuscript; available in PMC: 2023 May 20.
Published in final edited form as: Vaccine. 2022 Apr 22;40(23):3244–3252. doi: 10.1016/j.vaccine.2022.03.053

Table 3. Mean IgG titer values for oxycodone specific antibodies.

Male (M) and female (F) rats received four I injections of either alum adjuvant (Group 1), 1.43 (Group 2), or 68 (Groups 3 & 4) μg/animal Oxy(Gly)4-sKLH vaccine on Days 1, 15, 29, and 43 of the study. Oxycodone-specific serum IgG antibody titers were evaluated by ELISA on Day 50 (Dosing Phase) for 10 animals per group. Following oxycodone challenge 5 animals per sex from Groups 1 and 3 were allowed 4 weeks recovery and their oxycodone-specific serum IgG antibody titers were evaluated on Day 87 (Recovery Phase) of the study.

Group Details Dosing Phase Recovery Phase
Group
#		 Sex Figure1 N Mean SEM Mean SEM
1 M 3A 10 298 ± 70 - -
2 M 3A 10 48150 ± 9108 - -
3 M 3A 10 591559 ± 88242 - -
4 M 3A 10 376758 ± 49284 - -
1 F 3A 10 378 ± 175 - -
2 F 3A 10 80376 ± 14893 - -
3 F 3A 10 322839 ± 52660 - -
4 F 3A 10 377542 ± 60966 - -
1 M 3B 5 479 ± 259 224 ± 24
3 M 3B 5 465075 ± 132544 311291 ± 65980
1 F 3B 5 241 ± 40 200 ± 0
3 F 3B 5 316018 ± 18841 304521 ± 20456
1

Figure with associated data