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. Author manuscript; available in PMC: 2022 Jun 10.
Published in final edited form as: Ann Neurol. 2020 Sep 29;88(6):1065–1076. doi: 10.1002/ana.25874

Table 3.

Association of 5-Fold Higher Serum Concentration of Total Tau, Neurofilament Light, and Glial Fibrillary Acidic Protein with Baseline Level and Annual Rate of Decline in Global and Individual Tests of Cognition in 1,327 Participants from a Biracial Population Sample

Global Cognition
Coefficient (95% CI)
Memory Score
Coefficient (95% CI)
Speed Score
Coefficient (95% CI)
Increase in Baseline Score of Cognition1
T-Tau, pg/mL −0.110 (−0.172, −0.047) −0.100 (−0.027, −0.172) −0.113 (−0.039, −0.186)
Nf-L, pg/mL −0.237 (−0.142, −0.332) −0.168 (−0.058, −0.279) −0.314 (−0.203, −0.425)
GFAP, pg/mL −0.195 (−0.081, −0.310) −0.149 (−0.017, −0.281) −0.169 (−0.035, −0.305)

Increase in Annual Rate of Cognitive Decline2
T-Tau, pg/mL 0.009 (0.002, 0.016) 0.002 (−0.007, 0.011) −0.0004 (0.007, −0.008)
Nf-L, pg/mL 0.033 (0.022, 0.043) 0.022 (0.009, 0.035) 0.016 (0.005, 0.026)
GFAP, pg/mL 0.045 (0.033, 0.057) 0.016 (0.009, 0.021) 0.022 (0.010, 0.034)

NOTE: A linear mixed effects regression model with log10 transformed serum biomarkers adjusted for age, gender, race/ethnicity, education, and the presence of the APOE ε4 allele.

1

Negative baseline scores of cognition shows higher baseline biomarker concentrations were associated with lower standardized cognitive scores.

2

Positive annual rate of cognitive decline shows that higher baseline biomarker concentrations were associated with faster rate of cognitive decline.

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