Table 3.
Association of 5-Fold Higher Serum Concentration of Total Tau, Neurofilament Light, and Glial Fibrillary Acidic Protein with Baseline Level and Annual Rate of Decline in Global and Individual Tests of Cognition in 1,327 Participants from a Biracial Population Sample
Global Cognition Coefficient (95% CI) |
Memory Score Coefficient (95% CI) |
Speed Score Coefficient (95% CI) |
|
---|---|---|---|
Increase in Baseline Score of Cognition1 | |||
T-Tau, pg/mL | −0.110 (−0.172, −0.047) | −0.100 (−0.027, −0.172) | −0.113 (−0.039, −0.186) |
Nf-L, pg/mL | −0.237 (−0.142, −0.332) | −0.168 (−0.058, −0.279) | −0.314 (−0.203, −0.425) |
GFAP, pg/mL | −0.195 (−0.081, −0.310) | −0.149 (−0.017, −0.281) | −0.169 (−0.035, −0.305) |
| |||
Increase in Annual Rate of Cognitive Decline2 | |||
T-Tau, pg/mL | 0.009 (0.002, 0.016) | 0.002 (−0.007, 0.011) | −0.0004 (0.007, −0.008) |
Nf-L, pg/mL | 0.033 (0.022, 0.043) | 0.022 (0.009, 0.035) | 0.016 (0.005, 0.026) |
GFAP, pg/mL | 0.045 (0.033, 0.057) | 0.016 (0.009, 0.021) | 0.022 (0.010, 0.034) |
NOTE: A linear mixed effects regression model with log10 transformed serum biomarkers adjusted for age, gender, race/ethnicity, education, and the presence of the APOE ε4 allele.
Negative baseline scores of cognition shows higher baseline biomarker concentrations were associated with lower standardized cognitive scores.
Positive annual rate of cognitive decline shows that higher baseline biomarker concentrations were associated with faster rate of cognitive decline.