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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Nat Genet. 2022 May 12;54(5):725–734. doi: 10.1038/s41588-022-01065-4

Extended Data Fig. 3. Example Orca predictions of Polycomb-mediated interactions.

Extended Data Fig. 3

Predicted and observed H1-ESC and HFF genome interactions for two regions from a holdout chromosome, a). chr10:116850000-117850000 and b). chr10:100450000-101450000 are shown. The predicted and observed Polycomb-mediated interactions are marked with black triangles. ChIP-seq signal tracks for CTCF and H3K27me3 for the two cell types are also shown. Polycomb-mediated interactions are predicted to be specific to H1-ESC in both examples, consistent with experimental micro-C and ChIP-seq data.