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. 2021 Jul 2. Online ahead of print. doi: 10.1016/j.rcp.2021.06.002

Table 2.

Variables associated with mental health in medical students evaluated by the logistic regression analysis.

Variables Clinically relevant casesa/total of cases, n/N (%) P Adjusted Or* (95%CI)
Depression moderate-severe (Phq-9)
 Gender .039c
  Female 312/848 (37%) .039d 1.34 (1.01-1.75)
  Male 109/390 (28%) NA 1 (ref.)
 Academic period < .001c
  Pre-clinical (1st-3rd year) 230/591 (39%) < .001d 2.50 (1.38-4.52)
  Clinical (4th-6th year) 174/575 (30%) NA 1.50
  Internship (7th year) 1 (ref.)
 Economic stability .001c
  No 125/285 (44%) .001d 1.59 (1.19-2.11)
  Yes 296/953 (31%) NA 1 (ref.)
 Fear of damaging the medical training < .0001c
  A lot 143/301 (48%) < .0001d 2.67 (1.16-2.19)
  Much 111/330 (34%) .008d 1.49 (1.11-1.51)
  Nothing-a little 167/607 (28%) NA 1 (ref.)
 Fear of being late in finishing the career .015c
  A lot 159/324 (49%) .004d 1.59 (1.16-2.19)
  Much 144/435 (33%) NS 1.12 (.82-1.51)
  Nothing-a little 118/479 (25%) NA 1 (ref.)



Anxiety moderate-severe (Gad-7)
 Academic period < .001c
  Pre-clinical (1st-3rd year) 146/591 (25%) < .001d 2.35 (1.71-3.22)
  Clinical (4th-6th year) 83/575 (14%) NA 1 (ref.)
  Internship (7th year)e 6/72 (8%) - -
 Economic stability .001c
  No 82/285 (29%) .001d 2.05 (1.47-2.86)
  Yes 153/953 (16%) NA 1 (ref.)
 Fear of damaging the medical training < .001c
  A lot 90/301 (30%) < .001d 3.12 (2.01-4.76)
  Much 61/330 (18%) .001d 1.90 (1.29-2.80)
  Nothing-a little 84/607 (14%) NA 1 (ref.)
 Fear of being late in finishing the career < .022c
  A lot 99/324 (31%) < .007d 1.69 (1.16-2.48)
  Much 82/435 (19%) NS 1.15 (.79-1.68)
  Nothing-a little 54/579 (9%) NA 1 (ref.)



Distress moderate-severe (Iesr-9)
 Gender .008c
  Female 264/848 (31%) .008d 1.49 (1.01-1.97)
  Male 85/390 (22%) NA 1 (ref.)
 Age .013c
   >25 years old 44/129 (34%) .003d 2.82 (1.41-5.65)
  18-25 years old 291/1018 (29%) .011d 2.17 (1.12-3.95)
  < 18 years old 14/91 (15%) NA 1 (ref.)
 Academic period .001c
  Pre-clinical (1st-3rd year) 192/591 (32%) .012d 2.28 (1.20-4.33)
  Clinical (4th-6th year) 144/575 (25%) .267d 1.44 (.75-2.74)
  Internship (7th year) 13/72 (18%) NA 1 (ref.)
 Economic stability .016c
  No 97/285 (34%) .016d 1.44 (1.07-1.94)
  Yes 252/953 (26%) NA 1 (ref.)
 Lives with a person exposed to COVID-19 .041c
  No 184/704 (26%) .041d 1.31 (1.01-1.70)
  Yes 165/534 (31%) NA 1 (ref.)
 Fear of damaging the medical training < .001c
  A lot 122/324 (38%) < .001d 2.46 (1.78-3.40)
  Much 126/435 (29%) .005d 1.56 (1.14-2.21)
  Nothing-a little 101/479 (21%) NA 1 (ref.)

95%CI: 95% confidence interval; GAD-7: 7-item Generalized Anxiety Disorder; IES-R, 22-item Impact of Event Scale-Revised; NA: not applicable; NS: not significant (P >.05); OR: odds ratio; PHQ-9: 9-item Patient Health Questionnaire.

a

P-value calculated for logistic regression analysis.

c

Clinically relevant cases: students with moderate-severe symptoms of depression, anxiety and distress.

d

Adjusted for gender, age, academic period, economic stability, lives with a person exposed to COVID-19, fear of damaging the medical training and fear of being late the career, when appropriate.

e

This category was not considered because the number of individuals was not enough for analysis.

bP-value for each category vs reference.