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. 2022 May 13;9(6):819–829. doi: 10.1002/acn3.51562

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Nusinersen CSF levels are similar as participants age and grow. Body weight is predicted to have minimal impact upon the C _trough either at the 12‐mg or 28‐mg dose of nusinersen. Steady‐state trough concentrations were simulated over a wide range of body weights (9.0–114.5 kg). Despite an over 10‐fold change in body weight, the volume of the CNS is predicted not to change significantly over a wide range of body weights, leading to consistent exposure within the CNS. The total simulated patient population was divided into weight deciles (the range of body weights is presented on the x‐axis). The boxes represent 50% of the simulated population, bisected by the median value. The whiskers represent the predicted range for 95% of the simulated population. CNS = central nervous system; CSF = cerebrospinal fluid; C _trough = trough concentration.