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Effect of melatonin on gross cerebral infarct size, neurobehavioural outcome and cell death (A). Further stratified subgroup analysis to assess the efficacy of melatonin as a single therapy or as an adjunct agent with HT on combined neurological outcome (B). Forest plots of SMD with 95% CI ordered by effect size. Pooled estimate of effect size calculated using random effects model. SMD, standardised mean difference; HT, hypothermia.
