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. 2022 May;11(5):858–868. doi: 10.21037/tlcr-22-311

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2022 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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GEO database shows that macrophage polarization is significantly altered by NLRP3 depletion. (A,B) Gene profiles of NLRP3 (+/+) and NLRP3 (−/−) macrophages obtained from the GEO database (GSE183698) were compared and analyzed for the altered genes related to macrophage polarization. (A) A pathway enrichment analysis was performed using Metascape, showing that many pathways that were greatly altered were associated with inflammation and macrophage polarization (in red). (B) Significantly altered genes shown in a volcano map, with those associated with macrophage polarization highlighted. TGFβ1, transforming growth factor beta 1; VEGF-A, vascular endothelial growth factor A; IL, interleukin; NLRP3, NLR family pyrin domain containing 3; KO, knockout; WT, wildtype; iNOS, inducible nitric oxide synthase; GEO, Gene Expression Omnibus.