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NLRP3 depletion reduces lung metastasis of PDAC. Lung metastasis was determined by histology at 6 months. (A) A representative histological H&E staining image for lung metastasis (green arrow) of PDAC from a KC NLRP3 +/+ mouse. (B) Quantification of lung metastasis ratio. Scale bar was 200 µm. NLRP3, NLR family pyrin domain containing 3; PDAC, pancreatic ductal adenocarcinoma; KC, LSL-KrasG12D; H&E, hematoxylin and eosin.
