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. 2022 May;11(5):786–801. doi: 10.21037/tlcr-22-318

Figure 2.

Figure 2

Expression of selected six key ferroptosis regulators in LUAD. (A) Relative mRNA expression of GPX4, LPCAT3, KEAP1, NRF2, ACSL4, and FTH1 in LUAD and matched normal lung tissues. (B) Relative mRNA expression of GPX4, LPCAT3, KEAP1, NRF2, ACSL4, and FTH1 in LUAD and lung bronchial epithelial cell lines. (C) Protein expression levels of GPX4, LPCAT3, KEAP1, NRF2, ACSL4, and FTH1 in LUAD and matched normal lung tissues. (D) Protein expression levels of GPX4, LPCAT3, KEAP1, NRF2, ACSL4, and FTH1 in LUAD and lung bronchial epithelial cell lines. (E) Representative immunohistochemical images of GPX4 in different stage LUADs and matched normal lung tissues, scale bar =20 µm. *, P<0.05; ***, P<0.001. N, normal tissue; T, tumor tissue; n.s., not significant; LUAD, lung adenocarcinoma; mRNA, messenger RNA.