Table 1. Cox regression analysis of the GPX4 protein in LUAD patients from the tissue microarray.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| GPX4 expression (low vs. high) | 1.906 | 1.085–3.349 | 0.0248* | 2.490 | 1.359–4.562 | 0.003* | |
| Age (years) (<65 vs. ≥65) | 1.227 | 0.696–2.163 | 0.48 | – | – | – | |
| Sex (male vs. female) | 1.735 | 0.972–3.096 | 0.0622 | 2.532 | 1.340–4.784 | 0.004* | |
| TNM stage (III–IV vs. I–II) | 1.731 | 0.979–3.06 | 0.059 | 1.962 | 1.093–3.520 | 0.024* | |
| LNM (yes vs. no) | 1.332 | 0.763–2.324 | 0.314 | – | – | – | |
| Tumor size (cm) (≤3 vs. >3) | 1.368 | 0.760–2.464 | 0.296 | – | – | – | |
*, P<0.05. LUAD, lung adenocarcinoma; LNM, lymph node metastases; TNM, tumor-node-metastasis; HR, Hazard ratio; CI, confidence interval.