Table 3. Patient characteristics in univariate analysis of post hepatectomy liver failure (PHLF) in the Hokkaido University series.
| Characteristics | Hokkaido University | AMC/MSKCC 2017 (PHLFS) | |||||
|---|---|---|---|---|---|---|---|
| All patients (n=254) | Without PHLF (n=183) | With PHLF (n=71) | P value | Without PHLF (n=165) | With PHLF (n=52) | ||
| Sex (male/female) n [%] | 176 [69]/78 [31] | 129 [70]/54 [30] | 47 [66]/24 [34] | 0.506 | 106 [64]/59 [36] | 40 [77]/12 [23] | |
| Age (years); median [range] | 68 [43–86] | 68 [43–86] | 69 [48–79] | 0.313 | 64 [56–70] | 66 [48–79] | |
| Body mass index; median [range] | 22.0 [14.3–32.7] | 22.0 [14.3–32.7] | 21.9 [16.7–30.7] | 0.780 | 25 [23–28] | 25 [22–27] | |
| FLRV (mL); median [range] | 602 [295–1,427] | 666 [305–1,427] | 556 [295–1,040] | <0.001 | – | – | |
| FLRV (%); median [range] | 54.6 [22–95.4] | 61.6 [31.3–95.4] | 49.1 [22–85.2] | <0.001 | 60 [34–75] | 37 [26–61] | |
| Large (>45%); n [%] | 185 [73] | 141 [77] | 44 [62] | 0.008 | – | – | |
| Intermediate (30–45%); n [%] | 67 [26] | 42 [23] | 25 [35] | – | – | ||
| Small (<30%); n [%] | 2 [1] | 0 | 2 [3] | – | – | ||
| Jaundice (yes/no); n [%] | 199 [78]/55 [22] | 136 [74]/47[26] | 63 [89]/8 [11] | 0.012 | 109 [66]/56 [34] | 46 [88/6[12] | |
| FLR drainage (complete/incomplete); n | 254/0 | 183/0 | 71/0 | NA | – | – | |
| Preoperative cholangitis (yes/no); n [%] | 96 [38]/158 [62] | 59 [32]/124 [68] | 37 [52]/34 [48] | 0.004 | 37 [22]/128 [78] | 28 [54]/24 [46] | |
| Preoperative PVE (yes/no); n [%] | 117 [46]/137 [54] | 68 [37]/115 [63] | 49 [69]/22 [31] | <0.001 | – | – | |
| Type of liver resection; n [%] | |||||||
| Central | 1 | 0 | 1 | <0.001 | 1 | 1 | |
| Left (Ex) | 109 [43] | 96 [52] | 13 [18] | 65 [27] | 11 [6] | ||
| L3 | 17 [7] | 10 [5] | 7 [10] | – | – | ||
| Right (Ex) | 115 [45] | 71 [39] | 44 [62] | 24 [48] | 8 [26] | ||
| R3 | 12 [5] | 6 [3] | 6 [8] | – | – | ||
| Operative time (min); median [range] | 681 [385–1,252] | 663 [385–1,127] | 732 [479–1,252] | <0.001 | – | – | |
| Operative bleeding (mL); median [range] | 1670 [390–40,070] | 1500 [390–10,735] | 2210 [780–40,070] | <0.001 | – | – | |
| Portal vein reconstruction (yes/no); n [%] | 128 [51]/126 [49] | 84 [46]/99 [54] | 44 [62]/27 [38] | 0.021 | 24 [15]/141 [85] | 14 [27]/38 [73] | |
| Hepatic artery reconstruction (yes/no); n [%] | 32 [13]/222 [87] | 23[13]/160 [87] | 9 [13]/62 [87] | 0.982 | – | – | |
Values are presented as n or median (range in Hokkaido University; and interquartile range in PHLFS). “–”; not shown; PHLF, post hepatectomy liver failure; FLRV, future liver remnant volume; FLR, future liver remnant; PVE, portal vein embolization; central, central hepatectomy; left, left hepatectomy; L3, left trisectionectomy; right, right hepatectomy; R3, right trisectionectomy; Ex, extended hepatectomy including trisectionectomy; AMC, Academic Medial Center; MSKCC, Memorial Sloan Kettering Cancer Center; PHLFS, post hepatectomy liver failure score (Olthof et al. 2017).