Table 1. Stratified analysis of standardized mean difference of biological indicators in meta-analysis for patients with severe and mild disease.
| Anomaly indicator | Age (years) | SMD (95% CI) | P value | Heterogeneity I2 (%) | Sample size for mild | Sample size for severe | Included literature |
|---|---|---|---|---|---|---|---|
| Lymphocyte count | >55 | −0.42 (−0.5, −0.34) | <0.001 | 45 | 219 | 171 | 3 |
| <55 | −0.27 (−0.31, 0.24) | <0.001 | 48 | 301 | 71 | 3 | |
| IL-6 | >55 | 1.54 (1.29, 1.79) | <0.001 | 72 | 201 | 150 | 4 |
| <55 | 3.49 (2.99, 3.98) | <0.001 | 0 | 48 | 160 | 3 | |
| CRP | >55 | 0.48 (0.08, 0.89) | 0.02 | 38 | 175 | 159 | 3 |
| <55 | 3.53 (2.97, 4.08) | <0.001 | 51 | 65 | 325 | 3 | |
| D-D | >55 | 1.07 (0.79, 1.35) | <0.001 | 31 | 71 | 270 | 3 |
| <55 | 2.7 (2.29, 3.11) | <0.001 | 37 | 58 | 174 | 3 | |
| Neutrophil count | >55 | 0.44 (0.24, 0.65) | <0.001 | 80 | 191 | 270 | 4 |
| <55 | 1.79 (1.28, 2.3) | <0.001 | 0 | 29 | 68 | 2 |
SMD, standardized mean difference; 95% CI, confidence interval; IL-6, interleukin 6; CRP, C-reactive protein; D-D, D-dimer.