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. 2022 May;14(5):1478–1487. doi: 10.21037/jtd-22-345

Table 2. Characteristics of the included literature.

Author Research type Group Number of people Age (years) Complications
Qian GQ (10) Multicenter retrospective study Mild symptom 82 49 Not reported
Severe symptom 9 66 Not reported
Xie Y (11) Single retrospective study Mild symptom 22 58 Not reported
Severe symptom 7 69 Not reported
Zhu Z (12) Single retrospective study Mild symptom 111 49.9±15 High blood pressure 50%, heart disease 12.5%, cancer 6.25%, COPD 12.5%
Severe symptom 16 57.5±11 Diabetes 9.01%, hypertension 20.72%, heart disease 3.6%, cancer 3.6%, chronic obstructive pulmonary disease 3.6%
Zheng F (13) Single retrospective study Mild symptom 131 40 Diabetes 3.8%, hypertension 7.6%, heart disease 1.5%, chronic obstructive pulmonary disease 3.1%, cerebrovascular disease 2.3%, chronic liver disease 3.1%
Severe symptom 30 57 Diabetes 6.7%, hypertension 40%, heart disease 6.7%, chronic obstructive pulmonary disease 6.7%, cerebrovascular disease 3.3%
Lv Z (14) Multicenter retrospective study Mild symptom 115 62 Diabetes 7.83%, hypertension 20%, coronary heart disease 4.35%, chronic obstructive pulmonary disease 1.74%
Severe symptom 155 61 Diabetes 11.6%, hypertension 21.29%, heart disease 4.52%, chronic obstructive pulmonary disease 1.94%
Zhang G (15) Single retrospective study Mild symptom 166 51 Diabetes 9%, hypertension 16.9%, heart disease 5.4%, chronic obstructive pulmonary disease 1.2%, chronic kidney disease 0.6%, cerebrovascular disease 2.4%, chronic liver disease 1.8%, tumor 1.2%,
Severe symptom 55 62 Diabetes 12.7%, hypertension 47.3%, heart disease 23.6%, chronic obstructive pulmonary disease 7.3%, chronic kidney disease 9.1%, cerebrovascular disease 20%, chronic liver disease 7.3%, tumor 7.8%, immunosuppression 1.8%
Zhang H (16) Multicenter retrospective study Mild symptom 9 47±11.7 Not reported
Severe symptom 4 55.2±6 Not reported
Fu J (17) Single retrospective study Mild symptom 22 40.7±9 Hyperlipidemia 4.5%
Severe symptom 13 60±15.5 Diabetes 23.1%, hypertension 38.5%, chronic obstructive pulmonary disease 7.7%, cerebrovascular
Liu SL (18) Single retrospective study Mild symptom 194 43 Not reported
Severe symptom 31 64 Not reported
Liu Q (19) Multicenter retrospective study Mild symptom 59 49 Diabetes 3.4%, chronic kidney disease 4%, cerebrovascular disease 1.7%, chronic obstructive pulmonary disease 3.4%
Mild symptom 25 52 Diabetes 12%, chronic kidney disease 4%, heart disease 8%, cancer 4%, COPD 12%
Xu B (20) Single retrospective study Mild symptom 80 56 Not reported
Severe symptom 45 60 Not reported
Burgos-Blasco B (21) Single retrospective study Mild symptom 35 68.5 Cardiovascular disease 31%, chronic kidney disease 6%, chronic liver disease 6%, tumor 6%
Severe symptom 27 71 Cardiovascular disease 41%, chronic kidney disease 19%, chronic liver disease 4%, tumor 15%
Vultaggio A (22) Single retrospective study Mild symptom 63 72±13 Cardiovascular disease 41%, chronic kidney disease 19%, chronic liver disease 4%, tumor 15%
Severe symptom 145 63±15 Diabetes 27%, hypertension 58.7%, chronic lung disease 17.5%, cardiovascular disease 11.1%
Gao Y (23) Single retrospective study Mild symptom 28 42.96±14 Diabetes 3.57%, hypertension 25%, heart disease 8%
Severe symptom 15 45±7.68 Diabetes 40%, hypertension 40%, heart disease 6%
Zeng Z (24) Single retrospective study Mild symptom 93 59 Diabetes 18.3%, hypertension 43%, chronic kidney disease 3.2%, tumor 3.2%, chronic respiratory disease 4.3%, heart disease 10.8%
Severe symptom 167 62 Diabetes 18%, hypertension 36.5%, chronic kidney disease 0.6%, tumor 1.2%, chronic respiratory disease 5.9%, heart disease 10.8%, 8.4%
Liu J (25) Single retrospective study Mild symptom 13 59.7±10.1 Diabetes 30.8%, hypertension 38.5%, pituitary adenoma 7.7%
Severe symptom 27 43.2±12.3 Diabetes 7.4%, hypertension 3.7%, pituitary adenoma 3.7%

COPD, chronic obstructive pulmonary disease.