Table 3. Summary results of standardized mean difference of biological indicators in meta-analysis for patients with severe and mild disease.

Anomaly indicator	SMD (95% CI)	P value	I2 (%)	Number of studies	Patients with severe symptoms	Patients with mild symptoms
Inflammatory factors
IL-6	1.15 (1.01, 1.29)	<0.001	95	10	492	629
IL-4	0.2 (0.01, 0.39)	0.04	0	6	233	267
IL-10	0.92 (0.75, 1.08)	<0.001	98	3	383	399
SAA	2.82 (2.53, 3.11)	<0.001	88	5	101	401
CRP	1.42 (1.27, 1.57)	<0.001	98	11	368	918
Procalcitonin	1.16 (0.99, 1.33)	<0.001	98	5	396	338
Blood coagulation factors
D-D	1.18 (0.96, 1.4)	<0.001	93	6	129	444
APTT	0.63 (0.39, 0.87)	<0.001	83	4	97	254
P-T	1.83 (1.55, 2.11)	<0.001	89	4	97	254
Routine blood indexes
Lymphocyte count	−1.04 (−1.21, −0.86)	<0.001	96	7	257	548
Neutrophil count	0.63 (0.44, 0.82)	<0.001	87	6	220	338
Monocyte count	−0.56 (−0.8, −0.32)	<0.001	47	5	96	307
Platelets	−1.47 (−1.7, −1.24)	<0.001	97	6	117	536
Biochemical indicators
AST	2.75 (2.37, 3.12)	<0.001	91	4	61	252
ALT	2.72 (2.43, 3.02)	<0.001	96	4	92	446
ALB	−2.95 (−3.21, −2.7)	<0.001	93	4	229	408
LDH	4.01 (3.79, 4.24)	<0.001	84	6	351	704
Myocardial indexes
CK	2.62 (2.2, 3.03)	<0.001	87	4	50	180
CK-MB	3.07 (2.81, 3.34)	<0.001	92	4	138	462

SMD, standardized mean difference; 95% CI, confidence interval; I² (%), heterogeneity; IL-6, interleukin 6; IL-4, interleukin 4; IL-10, interleukin 10; SAA, serum amyloid A; CRP, C-reactive protein; D-D, D-dimer; APTT, activated partial thromboplastin time; P-T, prothrombin time; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, albumin; LDH, lactate dehydrogenase; CK, creatine kinase; CK-MB, creatine kinase MB isoenzyme.