Table 7. Univariate and multivariable associations of variables with mortality in patients with COVID-19.
| Variables | Univariate | Multivariable Model 1 | Multivariable Model 2 | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||
| Age (per 1 SD) | 1.51 (0.81–2.80) | 0.16 | – | – | – | – | ||
| Male sex | 2.02 (0.64–6.33) | 0.23 | – | – | – | – | ||
| CCI (per 1 SD) | 1.52 (0.82–2.84) | 0.18 | – | – | – | – | ||
| LDH (log-values per 1 SD) | 3.85 (1.37–10.80) | 0.011 | 2.72 (0.65–11.40) | 0.17 | 3.25 (0.80–13.24) | 0.10 | ||
| IL-6 (log-values per 1 SD) | 3.18 (1.32–7.69) | 0.010 | 4.08 (1.16–14.33) | 0.028 | 4.13 (1.21–14.10) | 0.024 | ||
| Presence of severe ARDS | 11.5 (2.26–59.0) | 0.003 | 3.35 (0.26–42.97) | 0.35 | – | – | ||
| Intubation | 8.10 (2.14–30.65) | 0.002 | – | – | 2.57 (0.44–14.89) | 0.29 | ||
| Duration NIV ≥5 days prior to ICU | 10.1 (1.1–91.8) | 0.040 | 42.20 (1.22 to >999) | 0.038 | 32.76 (1.02 to >999) | 0.049 | ||
Model 1: including severe ARDS, LDH (log-transformed), IL-6 (log-transformed), and duration NIV ≥5 days prior to ICU admission; Model 2: including intubation, LDH (log-transformed), IL-6 (log-transformed), and duration NIV ≥5 days prior to ICU admission. COVID-19, coronavirus disease 2019; OR, odds ratio; CI, confidence interval; SD, standard deviation; CCI, Charlson Comorbidity Index; LDH, lactate dehydrogenase; IL-6, interleukin-6; ARDS, acute respiratory distress syndrome; NIV, non-invasive ventilation; ICU, intensive care unit.