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. 2022 May;14(5):1544–1555. doi: 10.21037/jtd-22-423

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2022 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Examples of CTC (including diploid CTC and aneuploid CTC), WBC, and CTC-WBC cluster detected by the Subtraction Enrichment-iFISH platform. (A) Diploid CTCs are DAPI+/CD45−/Vimentin+ cells with diploid Chr8 (yellow arrow); WBCs are DAPI+/CD45+ cells with diploid Chr8 (white arrow). (B) Aneuploid CTCs are DAPI+/CD45− cells with aneuploid Chr8. (C) CTC-WBC cluster (the yellow arrow indicates CTC, and the white arrows indicate WBCs adhered to a CTC). The scale bars are 5 µm. DAPI, 4,6-diamino-2-phenyl indole; WBC, white blood cell; CTC, circulating tumor cell; CTC-WBC cluster, circulating tumor-cell-associated white blood cell cluster; iFISH, immunostaining-fluorescence in situ hybridization.