Table 2. Comparison of basic data of HFrEF, HFmrEF, and HFpEF patients.
| Variables | HFrEF (N=64) | HFmrEF (N=46) | HFpEF (N=196) | P value |
|---|---|---|---|---|
| Age (years) | 73.5 (68.0–78.0) | 72.5 (67.0–80.0) | 74.0 (68.0–80.0) | 0.532 |
| Male, n (%) | 40 (62.5) | 26 (56.5) | 97 (49.5) | 0.187 |
| Body mass index (kg/m2) | 23.5 (21.1–25.1) | 24.0 (21.5–26.3) | 24.6 (22.4–27.2) | 0.021 |
| Systolic blood pressure (mmHg) | 126 [118–134] | 128 [120–139] | 130 [120–144] | 0.035 |
| Diastolic blood pressure (mmHg) | 76 [72–81] | 72 [69–80] | 76 [70–81] | 0.234 |
| Smoker, n (%) | 27 (42.2) | 18 (39.1) | 64 (32.7) | 0.348 |
| Drinker, n (%) | 15 (23.4) | 14 (30.4) | 33 (16.8) | 0.096 |
| Hypertension, n (%) | 0.139 | |||
| None | 37 (57.8) | 21 (45.7) | 82 (41.8) | |
| Grade I | 2 (3.1) | 4 (8.7) | 10 (5.1) | |
| Grade II | 8 (12.5) | 10 (21.7) | 26 (13.3) | |
| Grade III | 17 (26.6) | 11 (23.9) | 78 (39.8) | |
| Diabetes, n (%) | 19 (29.7) | 18 (39.1) | 53 (27.0) | 0.278 |
| Cardiomyopathy, n (%) | 9 (14.0) | 1 (2.2) | 4 (2.0) | <0.001 |
| Coronary heart disease, n (%) | 42 (65.6) | 36 (78.2) | 125 (63.8) | 0.184 |
| Valvular disease, n (%) | 3 (4.6) | 2 (4.3) | 7 (3.6) | 0.915 |
| NYHA, n (%) | <0.001 | |||
| Grade II | 17 (26.6) | 26 (56.5) | 126 (64.3) | |
| Grade III | 22 (34.4) | 16 (34.8) | 59 (30.1) | |
| Grade IV | 25 (39.1) | 4 (8.7) | 11 (5.6) | |
| LVD (mm) | 58.0 (54.2–64.0) | 52.0 (49.0–57.0) | 47.0 (44.0–49.0) | <0.001 |
| LAD (mm) | 43.0 (38.2–46.0) | 40.0 (38.0–44.0) | 39.0 (35.0–43.0) | <0.001 |
| ALT (U/L) | 21.9 (13.8–28.5) | 19.35 (12.2–23.7) | 17.0 (13.0–27.1) | 0.314 |
| WBC (×109/L) | 6.4 (5.3–7.5) | 6.1 (4.9–7.6) | 6.0 (5.2–7.4) | 0.746 |
| RBC (×1012/L) | 4.3 (3.8–4.5) | 4.2 (3.9–4.6) | 4.1 (3.8–4.5) | 0.390 |
| Hemoglobin (g/L) | 130.0 (121.2–143.0) | 132.5 (120.7–147.0) | 131.0 (120.0–140.0) | 0.436 |
| Platelets (×109/L) | 171.5 (117.0–209.0) | 160.0 (141.7–200.5) | 168.0 (138.0–208.0) | 0.959 |
| Serum creatinine (μmol/L) | 84.4 (71.6–101.1) | 73.6 (58.7–89.9) | 72.5 (59.6–82.7) | <0.001 |
| NT-proBNP (pg/mL) | 2,400 (1,277–5,701) | 1,084 (606–2,776) | 785 (198–1,941) | <0.001 |
| sST2 (ng/mL) | 47.3 (24.5–53.6) | 30.6 (20.7–39.3) | 25.8 (16.5–38.9) | <0.001 |
| D-dimer (ng/mL) | 560.8 (355.0–1,071.0) | 523.6 (321.14–953.7) | 436.0 (302.0–703.0) | 0.055 |
| Glomerular filtration rate (mL/min/1.73 m2) | 61.9 (47.9–78.3) | 70.5 (56.2–88.2) | 72.3 (59.3–86.0) | 0.014 |
Data is presented as mean ± standard deviation or numbers and percentages. HFrEF, heart failure with reduced ejection fraction; HFmrEF, heart failure with mid-range ejection fraction; HFpEF, heart failure with preserved ejection fraction; NYHA, New York Heart Association; LVD, left ventricular end-diastolic diameter; LAD, left atrial diameter; ALT, alanine aminotransferase; WBC, white blood cell; RBC, red blood cell; NT-proBNP, NT-pro-brain natriuretic peptide; sST2, soluble suppression of tumorigenicity 2.