Table 2. MD Anderson criteria for evaluation of response in bone metastases.

Response type	Definition
Complete response	Complete fill-in or sclerosis of lytic lesion on CT or XR
	Disappearance of tumor signal on bone scan, CT, or MRI
	Normalization of osteoblastic lesion on CT or XR
Partial response	Sclerotic rim formation around initially lytic lesion on CT
	Sclerosis of lesions previously undetected on CT or XR
	Partial fill-in or sclerosis of lytic lesion on CT or XR
	Regression of measurable lesion on CT, MRI, or XR
	Regression of lesion on bone scan
	Decrease in blastic lesion on CT or XR
Stable disease	No change in measurable lesion on CT, MRI, or XR
	No change in blastic or lytic lesion or CT, MRI, or XR
	No new lesion on CT, MRI, or XR
Progressive disease	Increase in size of existing measurable lesion on CT, MRI, or XR
	New lesion on CT, MRI, bone scan, or XR
	Increase in lytic or blastic lesion on CT or XR

Ct, computed tomography; xr, plain radiography; Mri, magnetic resonance imaging. Adopted with publisher permission from (129).