Figure 1:

Initial conformation of the α-synuclein monomer (a) as resolved by solution NMR (PDB ID: 1XQ8), and (b) after heating at 500 K to obtain a randomized stretched conformation. Initial conformation for the fibril as derived by cryo-EM structures are shown in (c) for the rod (PDB ID: 6CU7) and in (d) for the twister (PDB ID: 6CU8) polymorph. In (e) and (f) are the corresponding structures shown for the fibrils where the individual chains are extended to residues 38–120. Acidic residues are colored in red and basic ones in blue, while the SK9-segments are shown yellow. The N- and C-termini are represented by green and orange spheres, respectively.