TABLE 3.

Primary sequences and physicochemical properties of Library 3 peptides, which correspond to W-position III shown in Figures 1G–I.

Name	Trp (W)	Sequence	Length (r)	Chargea	H	μH
E20	3	VV RR WR RR WR RW	12	7	0.177	0.904
E18	3	WV RR WR RV VR RW RR	14	8	0.166	0.914
E15	3	VV RR WR RV VR RW RR RW	16	9	0.159	0.86
E12	3	WV RR WR RV VR RW RR VV RR	18	10	0.153	0.865
E9	3	RW VR RW RR VV RR WR RV VR RV	20	11	0.148	0.864
E6	3	RR WV RR WR RV VR RW RR VV RR VV	22	12	0.144	0.834
E3	3	RR VV RR WR RV VR RW VR VW RR VV RR	24	13	0.141	0.824
E22	4	RR WV RV WR RW WR	12	6	0.448	1.002
E34	4	RR WV RV WR RW VR RW	14	7	0.399	0.995
E33	4	RR WV RV WR RW WR RV	14	7	0.399	0.962
E37	4	RR WV RV WR RW VR VW RR	16	8	0.363	0.931
E40	4	RR WV RV WR RW VR RW RR VV	18	9	0.334	0.923
E43	4	RR WV RV WR RW VR VW RR VV RR	20	10	0.311	0.884
E46	4	RR WR RV VR RW VR VW RR WV RR VR	22	12	0.191	0.87
E47	4	RR WR RV VR RW VR VW RR VV RR WR	22	12	9.191	0.88
E50	4	RR WR RV VR RW VR VW RR VV RR WR RV	24	13	0.184	0.873
E87	5	RR WV RV WR RW WR RW	14	7	0.473	1.035
E92	5	RR WV RW WR RW VR VW RR	16	8	0.427	0.955
E96	5	RR WV RV WR RW VR RW RR VW	18	9	0.391	0.966

H (hydrophobicity) and μH (hydrophobic moment) were determined using the online peptide modeling software heliquest.ipmc.cnrs.fr/; peptides of the same length are minor positional variants of W; r, residues.

The sequences were modeled as idealized amphipathic helices based on helical wheel diagrams using the online modeling software Heliquest, which also provides the physicochemical properties listed in the table.

^aAll charges are positive.